Sunday morning penance: small correction

The Moscone Centeer is indeed a vast place. ASCB is in Moscone South but in last night's blog I said that the American Geophysical Union (AGU) would be across the street in the other "half" of the Moscone. Apparently AGU will be in the Moscone West which is technically "across the street" if you cut across catty-corner. Accuracy, however, requires this correction. Also I've always wanted to use the word, "catty-corner," in a science context. I offer it up as a possible name for a Drosophila gene. Readers are invited to submit a possible phenotype for catty-corner.

Saturday morning, Saturday evening.

The fly-casters are back. Walking to my first ASCB Annual Meeting in 2000, I noticed all these other people confidently striding toward the convention center with what looked to be fishing rod cases strapped to their shoulders. Was there another meeting at the center for fly fishing enthusiasts? I soon discovered that the tubes contained tightly-rolled posters, not fishing tackle. 

This morning, the anglers/scientists were back on Howard Street in San Francisco, heading for the trout streams of cell biology that will flow through the cavernous Moscone Center for the next five days. Across the street in the other half of the Moscone, the American Geophysical Union will open its fall meeting on Monday. I wonder if I'll be able to spot the geologists by the rock hammers hanging from their belts. The ASCB is a Big Meeting. ASCB is expecting 10,000 attendees--scientists, students, press, exhibitors, and assorted dignitaries. But we're dwarfed the the AGU which routinely draws 15,000 to its fall meeting. 

Interestingly enough, geophysics and biology are drawing closer together as the effect of life on Earth and vice versa becomes more critical. One of the intriguing papers at ASCB is from Dianne K. Newman's "geobiology" lab at MIT. Her lab is focused on how ancestral bacteria on the early Earth evolved the ability to metabolize minerals. What might have seemed a purely academic question has led Newman and Lars Dietrich, a postdoctoral fellow in her lab, to new insights into the opportunistic infection that is the leading cause of death among the 30,000 Americans with cystic fibrosis. Dietrich will be presenting on Tuesday, so check back for more details on how genes can have different "purposes" in different organisms. Science aside, Dietrich has taken some striking images of bacterial colonies of Pseudomonas aeruginosa that he has been disrupting by gene silencing. More on those later. 

I type from the bowels of the Moscone Center where messengers come in from the outside to tell me how cold it is on the street. Well, cold by San Francisco standards. Soon I will go up the Moscone escalators to the vibrant streets of downtown San Francisco. How many American cities still have crowds of Christmas shoppers packing the downtown streets after dark? Recession or no, people here are shopping. 

Walking back to my hotel in the cold dark, I will have to push through the excited crowds outside the FAO Schwartz displays. Union Square is festooned with lights. A temporary skating rink in the park offers the intoxicating mix of ice and hot chocolate. Walking, I will think of lost cities and ghosts of Decembers past. Geologists, biologists, and window gazers, we've all come to SF for new wonders. 

Like a blog needs a bicycle

Friday, December 5, 2008

Like a blog needs a bicycle

We are a week away from the start of the ASCB Annual Meeting in SF for which I am supposed to produce a Cell Bio Blog. I've been wondering if I could volunteer for root canal work instead. I've never blogged and the very idea of it is unnerving. Where do I begin? Where does it all end?  

This morning, the NY Times reports the death of "HM," the legendary amnesiac studied for decades by Canadian psychologist Brenda Milner. HM, whose name the Times now reveals was Henry Moliason, died in a Connecticut nursing home on Tuesday night, aged 82. HM sustained brain trauma in a childhood bicycle accident. By the time he was in his mid-20s, HM was having blackouts and uncontrolled convulsions. Unable to work, HM sought out surgical help for these debilitating seizures. This was in the early 1950s. The neurosurgeon decided to ablate two narrow strips on the underside of his brain, transversing HM's hippocampus. It left him with a working memory about 30 seconds long. After that, everything and everyone was new to HM. The operation wasn't quackery. It reflected our primitive knowledge of how the brain was organized and how it functioned 60 years ago. Today the idea that any reputable surgeon would cut into the hippocampus is shocking. We know so much more, right?

But to get back to HM: from his misfortune, Dr. Milner was able to lay the basis for the modern study of memory. In those pre-MRI days, Dr. Milner used simple games and tests to probe the shape of HM's radically reordered mind. From her studies, she derived the notion of two kinds of memory. There is declarative memory by which we record names, faces, and new events and there is motor learning by which we learn new physical skills like shooting a basketball or riding a bike. Under Milner's watchful eye, HM was able to acquire new physical motor skills. He learned to retrace a pattern on paper while looking at his hand's movement only in a mirror. This is a difficult skill and HM got better and better at it every time he sat down to try it. Yet he had no memory of the test. The skill struck him as completely novel every time he attempted it. He had no declarative memory of the task and yet his motor learning grew sharper and sharper. In fact, HM had no declarative memory of Dr. Milner. Thirty seconds after she left the room, she vanished. Every time she returned, Dr. Milner was a novel face to HM.

So how does this apply to blogging? I've never blogged. Yet I've been writing on paper and on screens for decades, most recently as the Science Writer for the ASCB. So will blogging be a declarative experience or will I just pop up the kickstand and peddle away? You are invited to watch me. I might wobble off to destruction or slip quickly into old habits on a new machine as I blog from the 48th Annual Meeting of the American Society for Cell Biology. I find ASCB meetings to be equally enthralling and mind flattening. So much exciting new science, so many boring PPT slides. The idea of this blog is to point out some of the former and skip the later. 

I must also confess that my perspective at these meetings is different from that of the scientist members of the ASCB.  I'm a science writer and not a scientist. I go to a different meeting as it were. Hopefully, you can ride along with me. 

Meantime, I've got on my bicycle helmet, my pants clips, and my day-glow safety vest. SF or bust. One convention center, 6,000 cell biologists, and one brand new blogger.